May 18, 2022 Breaking News, Latest News, and Videos

UCLA Performs First ‘Breathing Lung’ Transplant In United States:

By Amy Albin

First there was the “heart in a box,” a revolutionary experimental technology that allows donor hearts to be delivered to transplant recipients warm and beating rather than frozen in an ice cooler.

Now that same technology is being used to deliver “breathing lungs.”

The lung transplant team at Ronald Reagan UCLA Medical successfully performed the nation’s first “breathing lung” transplant in mid-November. The patient, a 57-year-old who suffered from pulmonary fibrosis — a disease in which the air sacs of the lungs are gradually replaced by scar tissue — received two new lungs and is recuperating from the seven-hour surgery.

The groundbreaking transplant involved an experimental organ-preservation device known as the Organ Care System (OCS), which keeps donor lungs functioning and “breathing” in a near-physiologic state outside the body during transport. The current standard involves transporting donor lungs in a non-functioning, non-breathing state inside an icebox.

With the OCS, the lungs are removed from a donor’s body and are placed in a high-tech OCS box, where they are immediately revived to a warm, breathing state and perfused with oxygen and a special solution supplemented with packed red-blood cells. The device also features monitors that display how the lungs are functioning during transport.

“Organs were never meant to be frozen on ice,” said Dr. Abbas Ardehali, a professor of cardiothoracic surgery and director of the heart and lung transplantation program at Ronald Reagan UCLA Medical Center. “Lungs are very sensitive and can easily be damaged during the donation process. The cold storage method does not allow for reconditioning of the lungs before transplantation, but this promising ‘breathing lung’ technology enables us to potentially improve the function of the donor lungs before they are placed in the recipient.”

UCLA is currently leading the U.S. arm of the international, multicenter phase 2 clinical INSPIRE study of the OCS, developed by medical device company TransMedics; Ardehali is the principal investigator for UCLA. The purpose of the trial is to compare donor lungs transported using the OCS technology with the standard icebox method. The INSPIRE trial is also underway at lung transplant centers in Europe, Australia and Canada and will enroll a total of 264 randomized patients.

According to Ardehali, in addition to potentially improving donor-lung function, the technology could help transplant teams better assess donor lungs, since the organs can be tested in the device, over a longer period of time.

In addition, it could help expand the donor pool by allowing donor lungs to be safely transported across longer distances.

“For patients with end-stage lung disease, lung transplantation can dramatically improve the patient’s symptoms and offer relief from severe shortness of breath,” said Dr. David Ross, professor of medicine and medical director of UCLA’s lung and heart-lung transplantation program and UCLA’s pulmonary arterial hypertension and thromboendarterectomy program. “The ‘breathing lung’ technology could potentially make the transplantation process even better and improve the outcomes for patients suffering from lung disease.”

The “breathing lung” device follows on the heels of TransMedics’ “heart in a box” technology, which delivers donor hearts in a similar manner. The multi-center national study of the heart technology, also led by UCLA, is ongoing.

Results of a preliminary OCS lung study conducted in Europe were published in the Oct. 10 edition of the journal Lancet. The findings showed good lung transplantation outcomes following preservation using the OCS system, according to the Lancet study.

UCLA’s lung and heart-lung transplant program is the largest lung transplantation program on the West Coast and leads the nation in patient outcomes. The program pioneers novel technologies in lung preservation, recipient immune monitoring and immunosuppression and is responsible for significant advances in transplantation for extremely ill and high-risk transplant candidates.

For more information about UCLA’s lung transplantation program and the INSPIRE trial, visit www.transplant.ucla.edu/lung.

in News
Related Posts

Only 10 Vaquita Porpoises Survive, But The Species May Not Be Doomed

May 17, 2022

May 17, 2022

Hope remains for the porpoise species not only survive but thrive with human help. By Stuart Wolpert The vaquita porpoise,...

The American Cinematheque Brings “Bleak Week” To Santa Monica’s Aero Theatre And The Los Feliz Three Theatre

May 17, 2022

May 17, 2022

33 Films From 18 Countries In One Week. By Dolores Quintana Sometimes when things are tough and you’re feeling down,...

Man Who Murdered His Family Members Pleads Guilty To Five Other Killings

May 16, 2022

May 16, 2022

Escobar injured an additional seven other people as well.  By Dolores Quintana A man, Ramon Escobar, has pleaded guilty to...

The price of gasoline in Los Angeles County Has Experienced The Largest Increase Since February

May 16, 2022

May 16, 2022

Gasoline prices in Orange County Have Also Increased By Dolores Quintana Regular self-serve gasoline in the county of Los Angeles...

Santa Monica Travel Summit Of 2022 Returns To Take On Tomorrow

May 16, 2022

May 16, 2022

The Event Was Held At The Jonathan Club On Santa Monica Beach By Staff Writer The 2022 Santa Monica Tourism...

City Council Extends Santa Monica’s Parklet Program: Santa Monica Beat – May 16th, 2022

May 16, 2022

May 16, 2022

Local news and culture in under 5 minutes.* City Council Extends Santa Monica’s Parklet Program * Santa Monica High School Students...

1221 Ocean Avenue Complex Sold For Record Price

May 16, 2022

May 16, 2022

Sold for a record price of $330 million. By Dolores Quintana The Irvine Company has sold 1221 Ocean Avenue to...

Office Construction Is Starting To Rise In Los Angeles

May 15, 2022

May 15, 2022

Property vacancies are still affecting growth.  By Dolores Quintana In March, the Los Angeles Metropolitan area had 3.2 million square...

Santa Monica City Council Selects Doug Sloan as New City Attorney

May 12, 2022

May 12, 2022

At its meeting this week, the Santa Monica City Council appointed Doug Sloan to serve as Santa Monica’s next City...

Landmark Theater Closing in Former Westside Pavillion

May 12, 2022

May 12, 2022

Theater will close at the end of month By Sam Catanzaro The Landmark Pico theater at the former Westside Pavillion...

Community Policing at the Heart of Beat Four

May 11, 2022

May 11, 2022

The Neighborhood Resource Officer (NRO) Program thrives through community involvement and collective work. Today we hear from Officer Aaron Alpert...

Santa Monica High School Among Top-900 Schools in Country

May 10, 2022

May 10, 2022

SAMOHI ranked 829 out of over 18,000 total schools By Staff Writer Santa Monica High School is among the top...

Pico Marketplace Changing Small Businesses Access to Retail Space: Santa Monica Beat – May 10th, 2022

May 10, 2022

May 10, 2022

Local news and culture in under 5 minutes.* Pico Marketplace Changing Small Businesses Access to Retail Space* Grunion Fish Seen...

Video: Westside E-Scooter Injury Rate High Than National Rate for Motorcycles

May 10, 2022

May 10, 2022

The Westside’s injury rate for e-scooters is higher than the national rate for motorcycles, a new study has found. Learn...

Douglas Sloan Set to be Santa Monica’s New City Attorney

May 9, 2022

May 9, 2022

Sloan would be first permanent person to hold post in two years By Dolores Quintana  The next Santa Monica City...